![]() Definitive urine drug testing, given its high specificity and sensitivity, can accurately identify the use of specific prescription medications and illicit substances that, especially when taken with buprenorphine or other substances, may cause harm to a patient. Whether used on their own, concurrently, sequentially, or in combination, substances of abuse carry significant health risks. The literature showed that several common substances are often abused in conjunction with certain other substances, increasing the risk of serious adverse events, including death. ![]() In developing this article, the author conducted a search from May 2018 through December 2017 of peer-reviewed and government-supported articles in electronic databases. It is also intended to educate such practitioners on selecting appropriate testing technology to reduce risks to the health and safety of patients prescribed buprenorphine for opioid use disorder. ![]() This article is intended to educate practitioners in office-based opioid treatment settings on selecting appropriate substances for a definitive drug testing panel that are known to be used concurrently, sequentially, or in combination with buprenorphine for opioid use disorder. Urine drug testing is an important clinical tool for monitoring medication adherence and patient stability and screening for illicit drug use and dangerous drug-drug interactions. ![]() Individuals who receive buprenorphine treatment for opioid use disorder in office-based settings may be at risk for, or have a history of, polysubstance use. ![]()
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